Cytokine release syndrome is a well known complication of CAR-T therapy that can be treated with tocilizumab. This poster presents outcomes for patients treated with locally manufactured antiCD19 CAR-T cells showing that administration of prophylactic tocilizumab prior to infusion on CAR-T cells is associated with reduced incidence of severe CRS and decreased levels of clinical laboratory markers of inflammation and did not appear to impair disease control. |
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