Phase I Trial of MB-CART2019.1, a Novel CD20 and CD19 Targeting Tandem Chimeric Antigen Receptor, in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

This is the first phase 1 study to explore dual antigen-targeting CAR-T cells in DLBCL. The very preliminary phase 1 data suggests several agents will be pushing to larger trials. It is not clear how important antigen escape is following CD19-targeted CART cells but these trials might give us a clue.